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Features Plus

✔PEA is a naturally occurring fatty acid amide which affects endocannabinoid signalling. PEA achieves its analgesic effects via indirect activation of the cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptors; as well as indirect activation of PPAR-alpha, and several other receptors.

✔PEA has been explored since 1957 and has a clear analgesic and anti-inflammatory efficacy, and virtually no side effects. Meanwhile within the context of clinical trials 5000 patients have been using PEA, and its efficacy and safety has been documented in more than 500 scientific papers.

✔PEA is referred to as a natural painkiller and anti-inflammatory compound. PEA is produced in our cells and found in some foods.

✔PEA reduces the production of pro-inflammatory cytokines (e.g., TNF-α, IL-1β) and enzymes like COX-2 involved in inflammatory processes.

✔It down regulates mast cell activation, preventing the release of histamines and other inflammatory mediators.

✔PEA modulates the activity of glial cells in the nervous system. Overactivation of these cells contributes to neuropathic pain and chronic pain syndromes.

✔PEA has shown efficacy in managing various types of pain:

  • Neuropathic Pain: Conditions like sciatica, diabetic neuropathy, and post-herpetic neuralgia.
  • Inflammatory Pain: Arthritis, fibromyalgia, and musculoskeletal disorders.
  • Visceral Pain: Conditions like endometriosis and interstitial cystitis.
  • Chronic Pain Syndromes: Including complex regional pain syndrome (CRPS).
Ingredients Plus

Ultra-micronised Palmitoylethanolamide (P.E.A) in a cellulose capsule. 

Comes in 3 sizes 300mg, 600mg and 1000mg. 

See directions to determine what size for your pet. 

Directions & Storage Plus

For dogs and cats 1-15kg (300mg), Dogs 16-50kg (600mg), Dogs over 50kg (1000mg) or as directed by you veterinary care professional.

Keep out of reach of children

Cautions Plus

Ensure you purchase the correct size based on your pet's weight.

The Science Plus

Abramo, F., Campora, L., Albanese, F., della Valle, M. F., Cristino, L., Petrosino, S., ... & Miragliotta, V. (2014). Increased levels of palmitoylethanolamide and other bioactive lipid mediators and enhanced local mast cell proliferation in canine atopic dermatitis. BMC Veterinary Research, 10, 1-10.

Cerrato, S., Brazis, P., Della Valle, M. F., Miolo, A., Petrosino, S., Di Marzo, V., & Puigdemont, A. (2012). Effects of palmitoylethanolamide on the cutaneous allergic inflammatory response in Ascaris hypersensitive Beagle dogs. The Veterinary Journal, 191(3), 377-382.

della Rocca, G.; Re, G. Palmitoylethanolamide and Related ALIAmides for Small Animal Health: State of the Art. Biomolecules 2022, 12, 1186. https://doi.org/10.3390/biom12091186

della Rocca G, Gamba D. Chronic Pain in Dogs and Cats: Is There Place for Dietary Intervention with Micro-Palmitoylethanolamide? Animals. 2021; 11(4):952. https://doi.org/10.3390/ani11040952

Gugliandolo E, Peritore AF, Piras C, Cuzzocrea S, Crupi R. Palmitoylethanolamide and Related ALIAmides: Prohomeostatic Lipid Compounds for Animal Health and Wellbeing. Veterinary Sciences. 2020; 7(2):78. https://doi.org/10.3390/vetsci7020078

Noli, C., Della Valle, M. F., Miolo, A., Medori, C., Schievano, C., & Skinalia Clinical Research Group. (2015). Efficacy of ultra‐micronized palmitoylethanolamide in canine atopic dermatitis: an open‐label multi‐centre study. Veterinary dermatology, 26(6), 432-e101.

Petrosino, S., Schiano Moriello, A., Cerrato, S., Fusco, M., Puigdemont, A., De Petrocellis, L., & Di Marzo, V. (2016). The anti‐inflammatory mediator palmitoylethanolamide enhances the levels of 2‐arachidonoyl‐glycerol and potentiates its actions at TRPV1 cation channels. British Journal of Pharmacology, 173(7), 1154-1162.

Re, G., Barbero, R., Miolo, A., & Di Marzo, V. (2007). Palmitoylethanolamide, endocannabinoids and related cannabimimetic compounds in protection against tissue inflammation and pain: potential use in companion animals. The Veterinary Journal, 173(1), 21-30.

Scuderi C, Golini L. Successful and Unsuccessful Brain Aging in Pets: Pathophysiological Mechanisms behind Clinical Signs and Potential Benefits from Palmitoylethanolamide Nutritional Intervention. Animals. 2021; 11(9):2584. https://doi.org/10.3390/ani11092584

Customer Reviews

Based on 3 reviews
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A
Ange
2 years difference

My girls have been in this for 2 years
Has supported gut and joint health and massive difference in both

A
Alison
Alison

This product is a game changer for managing our older dogs pain and skin issues. The best on the market. I love it's dosed exactly to weight and the Roz is to knowledgeable any questions we had prior to purchase where answered in such detail.

A
Ange
PEA 1000mg

We were using a powdered PEA but swapped to these tablets that suited our big dog to help with pain. It has made such a difference in his mobility and pain management.