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PEA (Palmitoylethanolamide) (Size)
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PEA (Palmitoylethanolamide) (Size)
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Features Plus

The Senior Pet Bundle is designed to reduce cognitive decline, promote enhanced brain activity in dogs and cats, while also providing natural pain relief and relief of arthritic symptoms.

✔Lion's Mane contains bioactive substances that have many beneficial effects on the body, especially the brain, heart, and gut.

✔Studies have found that lion’s mane mushrooms contain two special compounds that can stimulate the growth of brain cells: hericenones and erinacines.

Reduce symptoms of memory loss , as well as prevent neuronal damage caused by amyloid-beta plaques, which accumulate in the brain during Alzheimer’s disease.

✔Other animal studies have found that lion’s mane extract can also help regenerate brain cells and improve the functioning of the hippocampus, a region of the brain that processes memories and emotional responses

Promotes Nerve Growth Factor (NGF): Compounds in Lion's Mane stimulate the production of NGF, a protein essential for the growth, repair, and protection of nerve cells.

Improves Memory and Focus: Regular consumption may enhance cognitive function, including memory, focus, and learning.

Supports Neuroprotection: Protects against neurodegenerative diseases by reducing oxidative stress and inflammation in the brain.

Aids in Nerve Repair: Known to support the regeneration of damaged nerves, making it potentially helpful in conditions like peripheral neuropathy.

Immunomodulatory Effects: Enhances the immune system by stimulating the activity of macrophages and other immune cells.

Rich in Antioxidants: Helps protect cells from damage caused by free radicals, thereby reducing inflammation and supporting immunity.

Protects the Stomach Lining: Lion's Mane has been shown to prevent and heal gastric ulcers by reducing inflammation and promoting the growth of healthy gut cells.

Supports Gut Microbiome: May improve gut health, which is linked to overall physical and mental well-being.

Reduces Systemic Inflammation: Effective in managing chronic inflammation, which is linked to various health conditions like heart disease and diabetes.

Prevents Cellular Aging: Antioxidants in Lion's Mane help fight oxidative stress, contributing to overall longevity and health.

✔PEA is a naturally occurring fatty acid amide which affects endocannabinoid signalling. PEA achieves its analgesic effects via indirect activation of the cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptors; as well as indirect activation of PPAR-alpha, and several other receptors.

✔PEA has been explored since 1957 and has a clear analgesic and anti-inflammatory efficacy, and virtually no side effects. Meanwhile within the context of clinical trials 5000 patients have been using PEA, and its efficacy and safety has been documented in more than 500 scientific papers.

✔PEA is referred to as a natural painkiller and anti-inflammatory compound. PEA is produced in our cells and found in some foods.

✔PEA reduces the production of pro-inflammatory cytokines (e.g., TNF-α, IL-1β) and enzymes like COX-2 involved in inflammatory processes.

✔It down regulates mast cell activation, preventing the release of histamines and other inflammatory mediators.

✔PEA modulates the activity of glial cells in the nervous system. Overactivation of these cells contributes to neuropathic pain and chronic pain syndromes.

✔PEA has shown efficacy in managing various types of pain:

Neuropathic Pain: Conditions like sciatica, diabetic neuropathy, and post-herpetic neuralgia.

Inflammatory Pain: Arthritis, fibromyalgia, and musculoskeletal disorders.

Visceral Pain: Conditions like endometriosis and interstitial cystitis.

✔Boswellia, also known as Indian Frankincense, is traditionally used in Indian Ayurvedic Medicine for its analgesic and anti-inflammatory properties particularly in arthritic and rheumatic conditions.

  • Willow Bark has been used traditionally in Western herbal medicine as an analgesic to relieve pain and to decrease symptoms of mild arthritis and mild osteoarthritis.
  • Help support healthy joint cartilage growth & joint health
  • Help maintain bone mineralisation & support bone health
  • Maintain general health & wellbeing
  • Rosehip contains polyphenols and anthocyanins, which are believed to ease joint inflammation and prevent joint damage. It’s also rich in vitamin C, which has antioxidant properties. Antioxidants are substances that can override harmful molecules (free radicals) which are produced within your cells and which may cause tissue damage or disease. Other studies have found that it can reduce the production of specific enzymes that break down cartilage.

Ingredients Plus

Lion's Mane

Each 1mL contains:

500mg of dried fruiting body equivalent Lion’s Mane (Hericium erinaceus)

Arthritis Care

Boswellia Serrata (Boswellia), Zingiber officinale (Ginger), Apium graveolens (Celery Seed), Salix Alba (White Willow Bark), Glucosamine Hydrochloride, Chondroitin, Rosa canina L. (Rosehips), Menyanthes (Bog Bean), Achillea millefolium (Yarrow), Taraxacum officinale (Dandelion Root)

PEA

Ultra-micronised Palmitoylethanolamide (P.E.A) in a cellulose capsule. 

Directions & Storage Plus

Store below 25 degrees Celsius. Keep in a cool dry place out of direct sunlight. Keep container tightly closed. Keep out of reach of children.

Cautions Plus

Discontinue 7 days prior to general anaesthesia or procedure when a sedative may be administered.

Do not give during pregnancy and lactation without professional veterinary supervision.

The Science Plus

Cho HW, Choi S, Seo K, Kim KH, Jeon JH, Kim CH, Lim S, Jeong S, Chun JL. Gut microbiota profiling in aged dogs after feeding pet food contained Hericium erinaceus. J Anim Sci Technol. 2022 Sep;64(5):937-949. doi: 10.5187/jast.2022.e66. Epub 2022 Sep 30. PMID: 36287790; PMCID: PMC9574611

Xiao, J. H., Xiao, D. M., Chen, D. X., Xiao, Y., Liang, Z. Q., & Zhong, J. J. (2012). Polysaccharides from the Medicinal Mushroom Cordyceps taii Show Antioxidant and Immunoenhancing Activities in a D‐Galactose‐Induced Aging Mouse Model. Evidence‐based Complementary and Alternative Medicine, 2012(1), 273435.

Andreani, G., Ferlizza, E., Macrì, E., Beghelli, D., & Isani, G. (2017). Effect of Boswellia serrata supplementation in addition to insulin on glycemic control in a diabetic dog. SLOVENIAN VETERINARY RESEARCH, 54(4), 173-179.

Caterino, C., Aragosa, F., Della Valle, G., Costanza, D., Lamagna, F., Piscitelli, A., ... & Fatone, G. (2021). Clinical efficacy of Curcuvet and Boswellic acid combined with conventional nutraceutical product: An aid to canine osteoarthritis. PLoS One, 16(5), e0252279.

Elisa, M., Mauro, B., Raffaella, A., Elena, B., Franco, D., Daniela, P., & Natascia, B. (2018). Evaluation of the efficacy of a dietary supplement in alleviating symptoms in dogs with osteoarthritis. JOURNAL OF FOOD AND NUTRITION, 4, 1-8.

Gabriele, V., Bisanzio, D., Riva, A., Meineri, G., Adami, R., & Martello, E. (2023). Long-term effects of a diet supplement containing Cannabis sativa oil and Boswellia serrata in dogs with osteoarthritis following physiotherapy treatments: a randomised, placebo-controlled and double-blind clinical trial. Natural Product Research, 37(11), 1782-1786.

Martello, E., Bigliati, M., Adami, R., Biasibetti, E., Bisanzio, D., Meineri, G., & Bruni, N. (2022). Efficacy of a dietary supplement in dogs with osteoarthritis: A randomized placebo-controlled, double-blind clinical trial. PLoS One, 17(2), e0263971.

Marstrand, K., & Campbell-Tofte, J. (2016). The role of rose hip (Rosa canina L) powder in alleviating arthritis pain and inflammation – part II animal and human studies. Botanics: Targets and Therapy, 6, 59–73. https://doi.org/10.2147/BTAT.S55573

Minami, S., Hata, M., Tamai, Y., Hashida, M., Takayama, T., Yamamoto, S., ... & Okamoto, Y. (2011). Clinical application of D-glucosamine and scale collagen peptide on canine and feline orthopedic diseases and spondylitis deformans. Carbohydrate polymers, 84(2), 831-834.

Musco, N., Vassalotti, G., Mastellone, V., Cortese, L., Della Rocca, G., Molinari, M. L., ... & Lombardi, P. (2019). Effects of a nutritional supplement in dogs affected by osteoarthritis. Veterinary medicine and science, 5(3), 325-335.

Neil, K. M., Caron, J. P., & Orth, M. W. (2005). The role of glucosamine and chondroitin sulfate in treatment for and prevention of osteoarthritis in animals. Journal of the American Veterinary Medical Association, 226(7), 1079-1088.

Reichling, J., Schmökel, H., Fitzi, J., Bucher, S., & Saller, R. (2004). Dietary support with Boswellia resin in canine inflammatory joint and spinal disease. Schweizer Archiv für Tierheilkunde, 146(2), 71-79.

Shakibaei, M., Allaway, D., Nebrich, S., & Mobasheri, A. (2012). Botanical extracts from Rosehip (Rosa canina), Willow Bark (Salix alba), and Nettle Leaf (Urtica dioica) suppress IL‐1β‐induced NF‐κB activation in canine articular chondrocytes. Evidence‐Based Complementary and Alternative Medicine, 2012(1), 509383.

Wenz, W., Hornung, C., Cramer, C., Schroeder, M., & Hoffmann, M. (2017). Effect of glucosamine sulfate on osteoarthritis in the cruciate-deficient canine model of osteoarthritis. Cartilage, 8(2), 173-179.

Abramo, F., Campora, L., Albanese, F., della Valle, M. F., Cristino, L., Petrosino, S., ... & Miragliotta, V. (2014). Increased levels of palmitoylethanolamide and other bioactive lipid mediators and enhanced local mast cell proliferation in canine atopic dermatitis. BMC Veterinary Research, 10, 1-10.

Cerrato, S., Brazis, P., Della Valle, M. F., Miolo, A., Petrosino, S., Di Marzo, V., & Puigdemont, A. (2012). Effects of palmitoylethanolamide on the cutaneous allergic inflammatory response in Ascaris hypersensitive Beagle dogs. The Veterinary Journal, 191(3), 377-382.

della Rocca, G.; Re, G. Palmitoylethanolamide and Related ALIAmides for Small Animal Health: State of the Art. Biomolecules 2022, 12, 1186. https://doi.org/10.3390/biom12091186

della Rocca G, Gamba D. Chronic Pain in Dogs and Cats: Is There Place for Dietary Intervention with Micro-Palmitoylethanolamide? Animals. 2021; 11(4):952. https://doi.org/10.3390/ani11040952

Gugliandolo E, Peritore AF, Piras C, Cuzzocrea S, Crupi R. Palmitoylethanolamide and Related ALIAmides: Prohomeostatic Lipid Compounds for Animal Health and Wellbeing. Veterinary Sciences. 2020; 7(2):78. https://doi.org/10.3390/vetsci7020078

Noli, C., Della Valle, M. F., Miolo, A., Medori, C., Schievano, C., & Skinalia Clinical Research Group. (2015). Efficacy of ultra‐micronized palmitoylethanolamide in canine atopic dermatitis: an open‐label multi‐centre study. Veterinary dermatology, 26(6), 432-e101.

Petrosino, S., Schiano Moriello, A., Cerrato, S., Fusco, M., Puigdemont, A., De Petrocellis, L., & Di Marzo, V. (2016). The anti‐inflammatory mediator palmitoylethanolamide enhances the levels of 2‐arachidonoyl‐glycerol and potentiates its actions at TRPV1 cation channels. British Journal of Pharmacology, 173(7), 1154-1162.

Re, G., Barbero, R., Miolo, A., & Di Marzo, V. (2007). Palmitoylethanolamide, endocannabinoids and related cannabimimetic compounds in protection against tissue inflammation and pain: potential use in companion animals. The Veterinary Journal, 173(1), 21-30.

Scuderi C, Golini L. Successful and Unsuccessful Brain Aging in Pets: Pathophysiological Mechanisms behind Clinical Signs and Potential Benefits from Palmitoylethanolamide Nutritional Intervention. Animals. 2021; 11(9):2584. https://doi.org/10.3390/ani11092584

 

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